43 results
Early technology review: towards an expedited pathway
- Leslie Levin, Murray Sheldon, Robert S. McDonough, Naomi Aronson, Maroeska Rovers, C. Michael Gibson, Sean Robert Tunis, Richard E. Kuntz
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- Journal:
- International Journal of Technology Assessment in Health Care / Volume 40 / Issue 1 / 2024
- Published online by Cambridge University Press:
- 29 January 2024, e13
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Objectives
Evidence development for medical devices is often focused on satisfying regulatory requirements with the result that health professional and payer expectations may not be met, despite considerable investment in clinical trials. Early engagement with payers and health professionals could allow companies to understand these expectations and reflect them in clinical study design, increasing chances of positive coverage determination and adoption into clinical practice.
MethodsAn example of early engagement through the EXCITE International model using an early technology review (ETR) is described which includes engagement with payers and health professionals to better inform companies to develop data that meet their expectations. ETR is based on an early evidence review, a framework of expectations that guides the process and identified gaps in evidence. The first fourteen ETRs were reviewed for examples of advice to companies that provided additional information from payers and health professionals that was thought likely to impact on downstream outcomes or strategic direction. Given that limitations were imposed by confidentiality, examples were genericized.
ResultsAdvice through early engagement can inform evidence development that coincides with expectations of payers and health professionals through a structured, objective, evidence-based approach. This could reduce the risk of business-related adverse outcomes such as failure to secure a positive coverage determination and/or acceptance by expert health professionals.
ConclusionsEarly engagement with key stakeholders exemplified by the ETR approach offers an alternative to the current approach of focusing on regulatory expectations. This could reduce the time to reimbursement and clinical adoption and benefit patient outcomes and/or health system efficiencies.
Improving the safety of rapid tranquilisation in older people
- Richard Harris, Rollo Sheldon, Jane McNulty, Scott Cherry
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- BJPsych Open / Volume 7 / Issue S1 / June 2021
- Published online by Cambridge University Press:
- 18 June 2021, p. S28
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Aims
To identify intramuscular rapid tranquilisation (IMRT) events in all >65 years inpatients in Sussex Partnership NHS Foundation Trust (SPFT) and to establish whether accompanying documentation meets SPFT guidelines. This is a re-audit, initial data were collected in 2016. Multimodal intervention has been implemented since initial data collection. In psychiatric inpatients IMRT should be administered as a last resort to calm acutely disturbed patients after verbal de-escalation and an offer of oral medication has failed. IMRT can cause physical health complications and impact therapeutic relationships. Quality improvements made since initial data collection were: an IMRT treatment algorithm for >65s, a teaching package for staff, IMRT prescription area on medicine cards and post IMRT physical monitoring forms – in line with updates to trust IMRT policy.
MethodRetrospective case note audit cycle of 119 patients. Electronic and paper records were reviewed for inpatients >65 years on 1/9/2019. Records were examined for instances of IMRT– the following features were noted: diagnosis; verbal de-escalation; oral medication offered prior to IMRT; IMRT prescription location; and post-IMRT monitoring. Descriptive statistics were performed. This audit was approved by the trust audit committee.
ResultThere were 34 RT events in 17 patients, reduced from 83 RT events in 20 patients in 2016. De-escalation was attempted in 62% versus 34% in 2016, oral medication offered first in 71% versus 59% in 2016. Physical monitoring was fully completed in 50% of instances in 2019, an improvement from 23% in 2016.
ConclusionEducation, a new treatment algorithm, medicine card changes, and IMRT physical monitoring forms have improved adherence to trust standards. There was a 49% reduction in IMRT events in 2019 versus 2016. De-escalation is being performed more frequently, and oral sedation offered in more cases. The physical monitoring of patients has improved.
Call 911: Lower Ambulance Utilization Among Young Adults, Especially Women, with Stroke
- Arunima Kapoor, M. Patrice Lindsay, Amy Y.X. Yu, Cristina Goia, Sheldon Cheskes, P. Richard Verbeek, Richard H. Swartz
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- Canadian Journal of Neurological Sciences / Volume 47 / Issue 6 / November 2020
- Published online by Cambridge University Press:
- 08 June 2020, pp. 764-769
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Background:
Delayed presentation to the emergency department influences acute stroke care and can result in worse outcomes. Despite public health messaging, many young adults consider stroke as a disease of older people. We determined the differences in ambulance utilization and delays to hospital presentation between women and men as well as younger (18–44 years) versus older (≥45 years) patients with stroke.
Methods:We conducted a population-based retrospective study using national administrative health data from the Canadian Institute of Health Information databases and examined data between 2003 and 2016 to compare ambulance utilization and time to hospital presentation across sex and age.
Results:Young adults account for 3.9% of 463,310 stroke/transient ischemic attack/hemorrhage admissions. They have a higher proportion of hemorrhage (37% vs. 15%) and fewer ischemic events (50% vs. 68%) compared with older patients. Younger patients are less likely to arrive by ambulance (62% vs. 66%, p < 0.001), with younger women least likely to use ambulance services (61%) and older women most likely (68%). Median stroke onset to hospital arrival times were 7 h for older patients and younger men, but 9 h in younger women. There has been no improvement among young women in ambulance utilization since 2003, whereas ambulance use increased in all other groups.
Conclusions:Younger adults, especially younger women, are less likely to use ambulance services, take longer to get to hospital, and have not improved in utilization of emergency services for stroke over 13 years. Targeted public health messaging is required to ensure younger adults seek emergency stroke care.
COVID-19: What paramedics need to know!
- Jason E. Buick, Sheldon Cheskes, Michael Feldman, P. Richard Verbeek, Morgan Hillier, Yuen Chin Leong, Ian R. Drennan
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- Canadian Journal of Emergency Medicine / Volume 22 / Issue 4 / July 2020
- Published online by Cambridge University Press:
- 15 April 2020, pp. 426-430
- Print publication:
- July 2020
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Richard Olney. Farming and Society in North Lincolnshire: The Dixons of Holton-Le-Moor, 1741–1906. The Lincoln Record Society. Woodbridge: Boydell Press, 2018. Pp. 214. $70.00 (cloth).
- Richard Sheldon
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- Journal:
- Journal of British Studies / Volume 58 / Issue 4 / October 2019
- Published online by Cambridge University Press:
- 24 October 2019, pp. 827-829
- Print publication:
- October 2019
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Evaluation of a primary care paramedic STEMI bypass guideline
- Jonathan L. Kwong, Garry Ross, Linda Turner, Chris Olynyk, Sheldon Cheskes, Adam Thurston, P. Richard Verbeek
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- Canadian Journal of Emergency Medicine / Volume 20 / Issue 6 / November 2018
- Published online by Cambridge University Press:
- 20 November 2017, pp. 850-856
- Print publication:
- November 2018
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Objective
Limited evidence supports primary care paramedic (PCP) direct transport of ST-segment elevation myocardial infarction (STEMI) patients for percutaneous coronary intervention (PCI). The goal of this study was to evaluate an urban-based PCP STEMI bypass guideline.
MethodsWe reviewed consecutive Toronto Paramedic Services call reports between April 7, 2015, and May 31, 2016, regarding STEMI patients identified by PCPs. The primary outcome was patient assignment (stable versus unstable) according to guideline criteria. Secondary outcomes were the proportion of PCP-transported patients who had an indication for an advanced care intervention (ACI) or who received an ACI when PCPs rendezvoused with an advanced care paramedic (ACP). Lastly, we reviewed prehospital outcomes of cardiac arrest patients and calculated the difference in transport intervals between direct PCP bypass and a PCI-centre and predicted transport interval to the closest emergency department (ED).
ResultsOf 361 patients, 232 were PCP transports and 129 were ACP-rendezvous transports. There was a significant difference in the distribution of stable and unstable patients between PCPs and ACPs (p<0.001). For PCP patients, 21/232 (9.1%) had indications for an ACI, whereas 34/129 (26.4%) ACP patients received an ACI. Eleven patients experienced cardiac arrest; 10 were successfully resuscitated (5 of these by PCPs). The median difference between direct PCP bypass and a PCI-centre versus transport to the closest ED was 5.53 minutes (IQR=6.71).
ConclusionsWe found a significant difference in the distribution of stable and unstable patients and fewer patients with indications for an ACI in PCP patients. This PCP STEMI bypass guideline appears feasible.
The onset of Arctic sea-ice snowmelt as detected with passive- and active-microwave remote sensing
- Richard R. Forster, David G. Long, Kenneth C. Jezek, Sheldon D. Drobot, Mark R. Anderson
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- Annals of Glaciology / Volume 33 / 2001
- Published online by Cambridge University Press:
- 14 September 2017, pp. 85-93
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Daily acquisitions from satellite microwave sensors can be used to observe the spatial and temporal characteristics of the Arctic sea-ice snowmelt onset because the initial presence of liquid water in a dry snowpack causes a dramatic change in the active-and passive-microwave response. A daily sequence of backscatter coefficient images from the NASA scatterometer (NSCAT) clearly shows the spatially continuous progression of decreasing backscatter associated with snowmelt onset across the Arctic Ocean during spring 1997. A time series of the active NSCAT backscatter and a scattering index from the passive Special Sensor Microwave/Imager (SSM/I) show similar trends during the time of the melt onset. An NSCATsnowmelt-onset detection algorithm is developed using the derivative of the backscatter with respect to time to select a melt-onset date for each pixel, generating a melt map for the Arctic sea ice. Comparison between this melt map and one previously generated from an SSM/I scattering index shows the NSCAT algorithm predicts the onset occurs 1−10 days earlier than the SSM/I-based algorithm for most portions of multi-year ice.
A global threats overview for Numeniini populations: synthesising expert knowledge for a group of declining migratory birds
- JAMES W. PEARCE-HIGGINS, DANIEL J. BROWN, DAVID J. T. DOUGLAS, JOSÉ A. ALVES, MARIAGRAZIA BELLIO, PIERRICK BOCHER, GRAEME M. BUCHANAN, ROB P. CLAY, JESSE CONKLIN, NICOLA CROCKFORD, PETER DANN, JAANUS ELTS, CHRISTIAN FRIIS, RICHARD A. FULLER, JENNIFER A. GILL, KEN GOSBELL, JAMES A. JOHNSON, ROCIO MARQUEZ-FERRANDO, JOSE A. MASERO, DAVID S. MELVILLE, SPIKE MILLINGTON, CLIVE MINTON, TAEJ MUNDKUR, ERICA NOL, HANNES PEHLAK, THEUNIS PIERSMA, FRÉDÉRIC ROBIN, DANNY I. ROGERS, DANIEL R. RUTHRAUFF, NATHAN R. SENNER, JUNID N. SHAH, ROB D. SHELDON, SERGEJ A. SOLOVIEV, PAVEL S. TOMKOVICH, YVONNE I. VERKUIL
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- Journal:
- Bird Conservation International / Volume 27 / Issue 1 / March 2017
- Published online by Cambridge University Press:
- 01 March 2017, pp. 6-34
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The Numeniini is a tribe of 13 wader species (Scolopacidae, Charadriiformes) of which seven are Near Threatened or globally threatened, including two Critically Endangered. To help inform conservation management and policy responses, we present the results of an expert assessment of the threats that members of this taxonomic group face across migratory flyways. Most threats are increasing in intensity, particularly in non-breeding areas, where habitat loss resulting from residential and commercial development, aquaculture, mining, transport, disturbance, problematic invasive species, pollution and climate change were regarded as having the greatest detrimental impact. Fewer threats (mining, disturbance, problematic native species and climate change) were identified as widely affecting breeding areas. Numeniini populations face the greatest number of non-breeding threats in the East Asian-Australasian Flyway, especially those associated with coastal reclamation; related threats were also identified across the Central and Atlantic Americas, and East Atlantic flyways. Threats on the breeding grounds were greatest in Central and Atlantic Americas, East Atlantic and West Asian flyways. Three priority actions were associated with monitoring and research: to monitor breeding population trends (which for species breeding in remote areas may best be achieved through surveys at key non-breeding sites), to deploy tracking technologies to identify migratory connectivity, and to monitor land-cover change across breeding and non-breeding areas. Two priority actions were focused on conservation and policy responses: to identify and effectively protect key non-breeding sites across all flyways (particularly in the East Asian- Australasian Flyway), and to implement successful conservation interventions at a sufficient scale across human-dominated landscapes for species’ recovery to be achieved. If implemented urgently, these measures in combination have the potential to alter the current population declines of many Numeniini species and provide a template for the conservation of other groups of threatened species.
Preliminary assessment of the scope and scale of illegal killing and taking of birds in the Mediterranean
- ANNE-LAURE BROCHET, WILLEM VAN DEN BOSSCHE, SHARIF JBOUR, P. KARIUKI NDANG’ANG’A, VICTORIA R. JONES, WED ABDEL LATIF IBRAHIM ABDOU, ABDEL RAZZAQ AL- HMOUD, NABEGH GHAZAL ASSWAD, JUAN CARLOS ATIENZA, IMAD ATRASH, NICHOLAS BARBARA, KEITH BENSUSAN, TAULANT BINO, CLAUDIO CELADA, SIDI IMAD CHERKAOUI, JULIETA COSTA, BERNARD DECEUNINCK, KHALED SALEM ETAYEB, CLAUDIA FELTRUP-AZAFZAF, JERNEJ FIGELJ, MARCO GUSTIN, PRIMOŽ KMECL, VLADO KOCEVSKI, MALAMO KORBETI, DRAŽEN KOTROŠAN, JUAN MULA LAGUNA, MATTEO LATTUADA, DOMINGOS LEITÃO, PAULA LOPES, NICOLÁS LÓPEZ-JIMÉNEZ, VEDRAN LUCIĆ, THIERRY MICOL, AÏSSA MOALI, YOAV PERLMAN, NICOLA PILUDU, DANAE PORTOLOU, KSENIJA PUTILIN, GWENAEL QUAINTENNE, GHASSAN RAMADAN-JARADI, MILAN RUŽIĆ, ANNA SANDOR, NERMINA SARAJLI, DARKO SAVELJIĆ, ROBERT D. SHELDON, TASSOS SHIALIS, NIKOS TSIOPELAS, FRAN VARGAS, CLAIRE THOMPSON, ARIEL BRUNNER, RICHARD GRIMMETT, STUART H.M. BUTCHART
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- Journal:
- Bird Conservation International / Volume 26 / Issue 1 / March 2016
- Published online by Cambridge University Press:
- 03 March 2016, pp. 1-28
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Illegal killing/taking of birds is a growing concern across the Mediterranean. However, there are few quantitative data on the species and countries involved. We assessed numbers of individual birds of each species killed/taken illegally in each Mediterranean country per year, using a diverse range of data sources and incorporating expert knowledge. We estimated that 11–36 million individuals per year may be killed/taken illegally in the region, many of them on migration. In each of Cyprus, Egypt, Italy, Lebanon and Syria, more than two million birds may be killed/taken on average each year. For species such as Blackcap Sylvia atricapilla, Common Quail Coturnix coturnix, Eurasian Chaffinch Fringilla coelebs, House Sparrow Passer domesticus and Song Thrush Turdus philomelos, more than one million individuals of each species are estimated to be killed/taken illegally on average every year. Several species of global conservation concern are also reported to be killed/taken illegally in substantial numbers: Eurasian Curlew Numenius arquata, Ferruginous Duck Aythya nyroca and Rock Partridge Alectoris graeca. Birds in the Mediterranean are illegally killed/taken primarily for food, sport and for use as cage-birds or decoys. At the 20 worst locations with the highest reported numbers, 7.9 million individuals may be illegally killed/taken per year, representing 34% of the mean estimated annual regional total number of birds illegally killed/taken for all species combined. Our study highlighted the paucity of data on illegal killing/taking of birds. Monitoring schemes which use systematic sampling protocols are needed to generate increasingly robust data on trends in illegal killing/taking over time and help stakeholders prioritise conservation actions to address this international conservation problem. Large numbers of birds are also hunted legally in the region, but specific totals are generally unavailable. Such data, in combination with improved estimates for illegal killing/taking, are needed for robustly assessing the sustainability of exploitation of birds.
Contributors
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- By Mitchell Aboulafia, Frederick Adams, Marilyn McCord Adams, Robert M. Adams, Laird Addis, James W. Allard, David Allison, William P. Alston, Karl Ameriks, C. Anthony Anderson, David Leech Anderson, Lanier Anderson, Roger Ariew, David Armstrong, Denis G. Arnold, E. J. Ashworth, Margaret Atherton, Robin Attfield, Bruce Aune, Edward Wilson Averill, Jody Azzouni, Kent Bach, Andrew Bailey, Lynne Rudder Baker, Thomas R. Baldwin, Jon Barwise, George Bealer, William Bechtel, Lawrence C. Becker, Mark A. Bedau, Ernst Behler, José A. Benardete, Ermanno Bencivenga, Jan Berg, Michael Bergmann, Robert L. Bernasconi, Sven Bernecker, Bernard Berofsky, Rod Bertolet, Charles J. Beyer, Christian Beyer, Joseph Bien, Joseph Bien, Peg Birmingham, Ivan Boh, James Bohman, Daniel Bonevac, Laurence BonJour, William J. Bouwsma, Raymond D. Bradley, Myles Brand, Richard B. Brandt, Michael E. Bratman, Stephen E. Braude, Daniel Breazeale, Angela Breitenbach, Jason Bridges, David O. Brink, Gordon G. Brittan, Justin Broackes, Dan W. Brock, Aaron Bronfman, Jeffrey E. Brower, Bartosz Brozek, Anthony Brueckner, Jeffrey Bub, Lara Buchak, Otavio Bueno, Ann E. Bumpus, Robert W. Burch, John Burgess, Arthur W. Burks, Panayot Butchvarov, Robert E. Butts, Marina Bykova, Patrick Byrne, David Carr, Noël Carroll, Edward S. Casey, Victor Caston, Victor Caston, Albert Casullo, Robert L. Causey, Alan K. L. Chan, Ruth Chang, Deen K. Chatterjee, Andrew Chignell, Roderick M. Chisholm, Kelly J. Clark, E. J. Coffman, Robin Collins, Brian P. Copenhaver, John Corcoran, John Cottingham, Roger Crisp, Frederick J. Crosson, Antonio S. Cua, Phillip D. Cummins, Martin Curd, Adam Cureton, Andrew Cutrofello, Stephen Darwall, Paul Sheldon Davies, Wayne A. Davis, Timothy Joseph Day, Claudio de Almeida, Mario De Caro, Mario De Caro, John Deigh, C. F. Delaney, Daniel C. Dennett, Michael R. DePaul, Michael Detlefsen, Daniel Trent Devereux, Philip E. Devine, John M. Dillon, Martin C. Dillon, Robert DiSalle, Mary Domski, Alan Donagan, Paul Draper, Fred Dretske, Mircea Dumitru, Wilhelm Dupré, Gerald Dworkin, John Earman, Ellery Eells, Catherine Z. Elgin, Berent Enç, Ronald P. Endicott, Edward Erwin, John Etchemendy, C. Stephen Evans, Susan L. Feagin, Solomon Feferman, Richard Feldman, Arthur Fine, Maurice A. Finocchiaro, William FitzPatrick, Richard E. Flathman, Gvozden Flego, Richard Foley, Graeme Forbes, Rainer Forst, Malcolm R. Forster, Daniel Fouke, Patrick Francken, Samuel Freeman, Elizabeth Fricker, Miranda Fricker, Michael Friedman, Michael Fuerstein, Richard A. Fumerton, Alan Gabbey, Pieranna Garavaso, Daniel Garber, Jorge L. A. Garcia, Robert K. Garcia, Don Garrett, Philip Gasper, Gerald Gaus, Berys Gaut, Bernard Gert, Roger F. Gibson, Cody Gilmore, Carl Ginet, Alan H. Goldman, Alvin I. Goldman, Alfonso Gömez-Lobo, Lenn E. Goodman, Robert M. Gordon, Stefan Gosepath, Jorge J. E. Gracia, Daniel W. Graham, George A. Graham, Peter J. Graham, Richard E. Grandy, I. Grattan-Guinness, John Greco, Philip T. Grier, Nicholas Griffin, Nicholas Griffin, David A. Griffiths, Paul J. Griffiths, Stephen R. Grimm, Charles L. Griswold, Charles B. Guignon, Pete A. Y. Gunter, Dimitri Gutas, Gary Gutting, Paul Guyer, Kwame Gyekye, Oscar A. Haac, Raul Hakli, Raul Hakli, Michael Hallett, Edward C. Halper, Jean Hampton, R. James Hankinson, K. R. Hanley, Russell Hardin, Robert M. Harnish, William Harper, David Harrah, Kevin Hart, Ali Hasan, William Hasker, John Haugeland, Roger Hausheer, William Heald, Peter Heath, Richard Heck, John F. Heil, Vincent F. Hendricks, Stephen Hetherington, Francis Heylighen, Kathleen Marie Higgins, Risto Hilpinen, Harold T. Hodes, Joshua Hoffman, Alan Holland, Robert L. Holmes, Richard Holton, Brad W. Hooker, Terence E. Horgan, Tamara Horowitz, Paul Horwich, Vittorio Hösle, Paul Hoβfeld, Daniel Howard-Snyder, Frances Howard-Snyder, Anne Hudson, Deal W. Hudson, Carl A. Huffman, David L. Hull, Patricia Huntington, Thomas Hurka, Paul Hurley, Rosalind Hursthouse, Guillermo Hurtado, Ronald E. Hustwit, Sarah Hutton, Jonathan Jenkins Ichikawa, Harry A. Ide, David Ingram, Philip J. Ivanhoe, Alfred L. Ivry, Frank Jackson, Dale Jacquette, Joseph Jedwab, Richard Jeffrey, David Alan Johnson, Edward Johnson, Mark D. Jordan, Richard Joyce, Hwa Yol Jung, Robert Hillary Kane, Tomis Kapitan, Jacquelyn Ann K. Kegley, James A. Keller, Ralph Kennedy, Sergei Khoruzhii, Jaegwon Kim, Yersu Kim, Nathan L. King, Patricia Kitcher, Peter D. Klein, E. D. Klemke, Virginia Klenk, George L. Kline, Christian Klotz, Simo Knuuttila, Joseph J. Kockelmans, Konstantin Kolenda, Sebastian Tomasz Kołodziejczyk, Isaac Kramnick, Richard Kraut, Fred Kroon, Manfred Kuehn, Steven T. Kuhn, Henry E. Kyburg, John Lachs, Jennifer Lackey, Stephen E. Lahey, Andrea Lavazza, Thomas H. Leahey, Joo Heung Lee, Keith Lehrer, Dorothy Leland, Noah M. Lemos, Ernest LePore, Sarah-Jane Leslie, Isaac Levi, Andrew Levine, Alan E. Lewis, Daniel E. Little, Shu-hsien Liu, Shu-hsien Liu, Alan K. L. Chan, Brian Loar, Lawrence B. Lombard, John Longeway, Dominic McIver Lopes, Michael J. Loux, E. J. Lowe, Steven Luper, Eugene C. Luschei, William G. Lycan, David Lyons, David Macarthur, Danielle Macbeth, Scott MacDonald, Jacob L. Mackey, Louis H. Mackey, Penelope Mackie, Edward H. Madden, Penelope Maddy, G. B. Madison, Bernd Magnus, Pekka Mäkelä, Rudolf A. Makkreel, David Manley, William E. Mann (W.E.M.), Vladimir Marchenkov, Peter Markie, Jean-Pierre Marquis, Ausonio Marras, Mike W. Martin, A. P. Martinich, William L. McBride, David McCabe, Storrs McCall, Hugh J. McCann, Robert N. McCauley, John J. McDermott, Sarah McGrath, Ralph McInerny, Daniel J. McKaughan, Thomas McKay, Michael McKinsey, Brian P. McLaughlin, Ernan McMullin, Anthonie Meijers, Jack W. Meiland, William Jason Melanson, Alfred R. Mele, Joseph R. Mendola, Christopher Menzel, Michael J. Meyer, Christian B. Miller, David W. Miller, Peter Millican, Robert N. Minor, Phillip Mitsis, James A. Montmarquet, Michael S. Moore, Tim Moore, Benjamin Morison, Donald R. Morrison, Stephen J. Morse, Paul K. Moser, Alexander P. D. Mourelatos, Ian Mueller, James Bernard Murphy, Mark C. Murphy, Steven Nadler, Jan Narveson, Alan Nelson, Jerome Neu, Samuel Newlands, Kai Nielsen, Ilkka Niiniluoto, Carlos G. Noreña, Calvin G. Normore, David Fate Norton, Nikolaj Nottelmann, Donald Nute, David S. Oderberg, Steve Odin, Michael O’Rourke, Willard G. Oxtoby, Heinz Paetzold, George S. Pappas, Anthony J. Parel, Lydia Patton, R. P. Peerenboom, Francis Jeffry Pelletier, Adriaan T. Peperzak, Derk Pereboom, Jaroslav Peregrin, Glen Pettigrove, Philip Pettit, Edmund L. Pincoffs, Andrew Pinsent, Robert B. Pippin, Alvin Plantinga, Louis P. Pojman, Richard H. Popkin, John F. Post, Carl J. Posy, William J. Prior, Richard Purtill, Michael Quante, Philip L. Quinn, Philip L. Quinn, Elizabeth S. Radcliffe, Diana Raffman, Gerard Raulet, Stephen L. Read, Andrews Reath, Andrew Reisner, Nicholas Rescher, Henry S. Richardson, Robert C. Richardson, Thomas Ricketts, Wayne D. Riggs, Mark Roberts, Robert C. Roberts, Luke Robinson, Alexander Rosenberg, Gary Rosenkranz, Bernice Glatzer Rosenthal, Adina L. Roskies, William L. Rowe, T. M. Rudavsky, Michael Ruse, Bruce Russell, Lilly-Marlene Russow, Dan Ryder, R. M. Sainsbury, Joseph Salerno, Nathan Salmon, Wesley C. Salmon, Constantine Sandis, David H. Sanford, Marco Santambrogio, David Sapire, Ruth A. Saunders, Geoffrey Sayre-McCord, Charles Sayward, James P. Scanlan, Richard Schacht, Tamar Schapiro, Frederick F. Schmitt, Jerome B. Schneewind, Calvin O. Schrag, Alan D. Schrift, George F. Schumm, Jean-Loup Seban, David N. Sedley, Kenneth Seeskin, Krister Segerberg, Charlene Haddock Seigfried, Dennis M. Senchuk, James F. Sennett, William Lad Sessions, Stewart Shapiro, Tommie Shelby, Donald W. Sherburne, Christopher Shields, Roger A. Shiner, Sydney Shoemaker, Robert K. Shope, Kwong-loi Shun, Wilfried Sieg, A. John Simmons, Robert L. Simon, Marcus G. Singer, Georgette Sinkler, Walter Sinnott-Armstrong, Matti T. Sintonen, Lawrence Sklar, Brian Skyrms, Robert C. Sleigh, Michael Anthony Slote, Hans Sluga, Barry Smith, Michael Smith, Robin Smith, Robert Sokolowski, Robert C. Solomon, Marta Soniewicka, Philip Soper, Ernest Sosa, Nicholas Southwood, Paul Vincent Spade, T. L. S. Sprigge, Eric O. Springsted, George J. Stack, Rebecca Stangl, Jason Stanley, Florian Steinberger, Sören Stenlund, Christopher Stephens, James P. Sterba, Josef Stern, Matthias Steup, M. A. Stewart, Leopold Stubenberg, Edith Dudley Sulla, Frederick Suppe, Jere Paul Surber, David George Sussman, Sigrún Svavarsdóttir, Zeno G. Swijtink, Richard Swinburne, Charles C. Taliaferro, Robert B. Talisse, John Tasioulas, Paul Teller, Larry S. Temkin, Mark Textor, H. S. Thayer, Peter Thielke, Alan Thomas, Amie L. Thomasson, Katherine Thomson-Jones, Joshua C. Thurow, Vzalerie Tiberius, Terrence N. Tice, Paul Tidman, Mark C. Timmons, William Tolhurst, James E. Tomberlin, Rosemarie Tong, Lawrence Torcello, Kelly Trogdon, J. D. Trout, Robert E. Tully, Raimo Tuomela, John Turri, Martin M. Tweedale, Thomas Uebel, Jennifer Uleman, James Van Cleve, Harry van der Linden, Peter van Inwagen, Bryan W. Van Norden, René van Woudenberg, Donald Phillip Verene, Samantha Vice, Thomas Vinci, Donald Wayne Viney, Barbara Von Eckardt, Peter B. M. Vranas, Steven J. Wagner, William J. Wainwright, Paul E. Walker, Robert E. Wall, Craig Walton, Douglas Walton, Eric Watkins, Richard A. Watson, Michael V. Wedin, Rudolph H. Weingartner, Paul Weirich, Paul J. Weithman, Carl Wellman, Howard Wettstein, Samuel C. Wheeler, Stephen A. White, Jennifer Whiting, Edward R. Wierenga, Michael Williams, Fred Wilson, W. Kent Wilson, Kenneth P. Winkler, John F. Wippel, Jan Woleński, Allan B. Wolter, Nicholas P. Wolterstorff, Rega Wood, W. Jay Wood, Paul Woodruff, Alison Wylie, Gideon Yaffe, Takashi Yagisawa, Yutaka Yamamoto, Keith E. Yandell, Xiaomei Yang, Dean Zimmerman, Günter Zoller, Catherine Zuckert, Michael Zuckert, Jack A. Zupko (J.A.Z.)
- Edited by Robert Audi, University of Notre Dame, Indiana
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- The Cambridge Dictionary of Philosophy
- Published online:
- 05 August 2015
- Print publication:
- 27 April 2015, pp ix-xxx
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5 - ‘A Loud, a Fervid, and Resolute Remonstrance with our Rulers’: John Thelwall, the People and Political Economy
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- By Richard Sheldon, University of Bristol
- Edited by Steve Poole
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- John Thelwall
- Published by:
- Pickering & Chatto
- Published online:
- 05 December 2014, pp 61-70
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Summary
Thelwall's best-known public oration was staged on 26 October 1795 at the giant open-air meeting at Copenhagen Fields to protest against war, the high price of bread and the absence of effective political representation. Three days later came the attack on George III's coach at the opening of parliament by crowds clamouring for peace and a reduction in the price of bread, threatening ‘a king without a head’, if their demands were not met. These events marked only the crescendo of an argument that commenced earlier in the year as food prices inexorably rose and as riot and popular agitation spilled onto the streets. For Thelwall the deep cause of the crisis lay in the absence of political representation, and the solution was to be sought in ‘a loud, a fervid, and resolute remonstrance with our rulers’. ‘Remonstrance’ of course is a gesture towards the long shadow cast by the political contests of the seventeenth century, suggesting to the historically-minded the precedence of the Great Remonstrance presented to Charles I at the Long Parliament, which had complained amongst other things about the burden of maintaining long and costly wars. But Thelwall's pronouncements in this year, delivered as lectures, then published in The Tribune, have been freighted with extra significance, suggesting indeed a watershed in political thought: the moment at which the powerful modern sociology of political economy was first set out in defence of the labouring poor. This essay explores the nature of Thelwall's contribution to what might be termed the political economy of English Jacobinism.
Interest in Thelwall as an English Jacobin theorist has grown in recent years; he has also come to occupy a crucial position in the historiography of British radicalism, so much so that a careful review of precisely what he said, together with its context, is required in order both to move away from some inaccurate portrayals of his politics and to recapture the true sources of his originality.
Factors Associated with Concomitant Psychotropic Drug Use in the Treatment of Major Depression: A STAR*D Report
- Richard C. Shelton, Steve D. Hollon, Stephen R. Wisniewski, Jonathan E. Alpert, G.K. Balasubramani, Edward S. Friedman, A. John Rush, Madhukar H. Trivedi, Sheldon H. Preskorn
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- Journal:
- CNS Spectrums / Volume 14 / Issue 9 / September 2009
- Published online by Cambridge University Press:
- 07 November 2014, pp. 487-498
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Introduction: Concomitant psychotropic medication (CPM) treatment is common in persons with major depression (MDD). However, relationships with patient characteristics and response to treatment are unclear.
Methods: Participants with nonpsychotic MDD (N=2682) were treated with citalopram, 20–60 mg/day. Sociodemographic, clinical, and treatment outcome characteristics were compared between those using CPMs at study entry or during up to 14 weeks of citalopram treatment, and non-users.
Results: About 35% of participants used a CPM. Insomnia was the predominant indication (70.3%). CPM users were more likely to be seen in primary care settings (69.3% versus 30.7%), be white, of non-Hispanic ethnicity, married, and have a higher income, private insurance, and certain comorbid disorders. CPM users had greater depressive severity, poorer physical and mental functioning, and poorer quality of life than non-users. Response and remission rates were also lower. CPM users were more likely to achieve ≥50 mg/day of citalopram, to report greater side effect intensity, and to have serious adverse events, but less likely to be intolerant of citalopram.
Conclusion: CPMs are associated with greater illness burden, more Axis I comorbidities (especially anxiety disorders), and lower treatment effectiveness. This suggests that CPM use may identify a more difficult to treat population that needs more aggressive treatment.
Contributors
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- By Rene Almeling, John B. Appleby, Lucy Blake, Kate Bourne, Andrea Mechanick Braverman, Naomi Cahn, Lorraine Culley, Fatemeh Ebtehaj, Jeannette Edwards, Tabitha Freeman, Lucy Frith, Susan Golombok, Susanna Graham, Cathy Herbrand, Nicky Hudson, Susan Imrie, Vasanti Jadva, Sarah Jennings, Anja J. Karnein, Hallvard Lillehammer, Julie McCandless, Petra Nordqvist, Guido Pennings, Veerle Provoost, Martin Richards, Sally Sheldon, Carol Smart, Marcin Smietana, Venessa Smith, Helen Statham, Sophie Zadeh, Irenee Daly, Yolanda Garcia-Ruiz, Zeynep Gürtin, Robert Klitzman, Soraya Tremayne, Sheryl Vanderpoel, Effy Vayena, Katharine Wright
- Edited by Tabitha Freeman, University of Cambridge, Susanna Graham, University of Cambridge, Fatemeh Ebtehaj, University of Cambridge, Martin Richards, University of Cambridge
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- Book:
- Relatedness in Assisted Reproduction
- Published online:
- 05 August 2014
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- 14 August 2014, pp vii-ix
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Effectiveness of Common Healthcare Disinfectants against H1N1 Influenza Virus on Reusable Elastomeric Respirators
- Shobha S. Subhash, Maria Cavaiuolo, Lewis J. Radonovich, Jr, Aaron Eagan, Martin L. Lee, Sheldon Campbell, Richard A. Martinello
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- Journal:
- Infection Control & Hospital Epidemiology / Volume 35 / Issue 7 / July 2014
- Published online by Cambridge University Press:
- 10 May 2016, pp. 894-897
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- July 2014
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This study evaluated the efficacy of 3 common hospital disinfectants to inactivate influenza virus on elastomeric respirators. Quaternary ammonium/isopropyl alcohol and bleach detergent wipes eliminated live virus, whereas 70% isopropyl alcohol alone was ineffective.
Infect Control Hosp Epidemiol 2014;35(7):894–897
Contributors
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- By Lenard A. Adler, Pinky Agarwal, Rehan Ahmed, Jagga Rao Alluri, Fawaz Al-Mufti, Samuel Alperin, Michael Amoashiy, Michael Andary, David J. Anschel, Padmaja Aradhya, Vandana Aspen, Esther Baldinger, Jee Bang, George D. Baquis, John J. Barry, Jason J. S. Barton, Julius Bazan, Amanda R. Bedford, Marlene Behrmann, Lourdes Bello-Espinosa, Ajay Berdia, Alan R. Berger, Mark Beyer, Don C. Bienfang, Kevin M. Biglan, Thomas M. Boes, Paul W. Brazis, Jonathan L. Brisman, Jeffrey A. Brown, Scott E. Brown, Ryan R. Byrne, Rina Caprarella, Casey A. Chamberlain, Wan-Tsu W. Chang, Grace M. Charles, Jasvinder Chawla, David Clark, Todd J. Cohen, Joe Colombo, Howard Crystal, Vladimir Dadashev, Sarita B. Dave, Jean Robert Desrouleaux, Richard L. Doty, Robert Duarte, Jeffrey S. Durmer, Christyn M. Edmundson, Eric R. Eggenberger, Steven Ender, Noam Epstein, Alberto J. Espay, Alan B. Ettinger, Niloofar (Nelly) Faghani, Amtul Farheen, Edward Firouztale, Rod Foroozan, Anne L. Foundas, David Elliot Friedman, Deborah I. Friedman, Steven J. Frucht, Oded Gerber, Tal Gilboa, Martin Gizzi, Teneille G. Gofton, Louis J. Goodrich, Malcolm H. Gottesman, Varda Gross-Tsur, Deepak Grover, David A. Gudis, John J. Halperin, Maxim D. Hammer, Andrew R. Harrison, L. Anne Hayman, Galen V. Henderson, Steven Herskovitz, Caitlin Hoffman, Laryssa A. Huryn, Andres M. Kanner, Gary P. Kaplan, Bashar Katirji, Kenneth R. Kaufman, Annie Killoran, Nina Kirz, Gad E. Klein, Danielle G. Koby, Christopher P. Kogut, W. Curt LaFrance, Patrick J.M. Lavin, Susan W. Law, James L. Levenson, Richard B. Lipton, Glenn Lopate, Daniel J. Luciano, Reema Maindiratta, Robert M. Mallery, Georgios Manousakis, Alan Mazurek, Luis J. Mejico, Dragana Micic, Ali Mokhtarzadeh, Walter J. Molofsky, Heather E. Moss, Mark L. Moster, Manpreet Multani, Siddhartha Nadkarni, George C. Newman, Rolla Nuoman, Paul A. Nyquist, Gaia Donata Oggioni, Odi Oguh, Denis Ostrovskiy, Kristina Y. Pao, Juwen Park, Anastas F. Pass, Victoria S. Pelak, Jeffrey Peterson, John Pile-Spellman, Misha L. Pless, Gregory M. Pontone, Aparna M. Prabhu, Michael T. Pulley, Philip Ragone, Prajwal Rajappa, Venkat Ramani, Sindhu Ramchandren, Ritesh A. Ramdhani, Ramses Ribot, Heidi D. Riney, Diana Rojas-Soto, Michael Ronthal, Daniel M. Rosenbaum, David B. Rosenfield, Durga Roy, Michael J. Ruckenstein, Max C. Rudansky, Eva Sahay, Friedhelm Sandbrink, Jade S. Schiffman, Angela Scicutella, Maroun T. Semaan, Robert C. Sergott, Aashit K. Shah, David M. Shaw, Amit M. Shelat, Claire A. Sheldon, Anant M. Shenoy, Yelizaveta Sher, Jessica A. Shields, Tanya Simuni, Rajpaul Singh, Eric E. Smouha, David Solomon, Mehri Songhorian, Steven A. Sparr, Egilius L. H. Spierings, Eve G. Spratt, Beth Stein, S.H. Subramony, Rosa Ana Tang, Cara Tannenbaum, Hakan Tekeli, Amanda J. Thompson, Michael J. Thorpy, Matthew J. Thurtell, Pedro J. Torrico, Ira M. Turner, Scott Uretsky, Ruth H. Walker, Deborah M. Weisbrot, Michael A. Williams, Jacques Winter, Randall J. Wright, Jay Elliot Yasen, Shicong Ye, G. Bryan Young, Huiying Yu, Ryan J. Zehnder
- Edited by Alan B. Ettinger, Albert Einstein College of Medicine, New York, Deborah M. Weisbrot, State University of New York, Stony Brook
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- Book:
- Neurologic Differential Diagnosis
- Published online:
- 05 June 2014
- Print publication:
- 17 April 2014, pp xi-xx
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Contributors
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- By Leslie Citrome, Alan J. Cross, Judith Dunn, Kenneth R. Evans, Douglas E. Feltner, Philip D. Harvey, Amir Kalali, Richard S. E. Keefe, Michael Krams, Joseph Kwentus, Matthew Macaluso, Craig H. Mallinckrodt, Geert Molenberghs, Nuala Murphy, Ginette Nachman, Sheldon Preskorn, William R. Prucka, Penny Randall, Frank D. Yocca, Gwen L. Zornberg
- Edited by Amir Kalali, University of California, San Diego, Sheldon Preskorn, Joseph Kwentus, University of Mississippi, Stephen M. Stahl, University of California, San Diego
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- Book:
- Essential CNS Drug Development
- Published online:
- 05 July 2012
- Print publication:
- 07 June 2012, pp vi-viii
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5 - Development, Poverty & Famines
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- By Richard Sheldon, University of Bristol
- Edited by Mark Duffield, University of Bristol, Vernon Hewitt, University of Bristol
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- Book:
- Empire, Development and Colonialism
- Published by:
- Boydell & Brewer
- Published online:
- 05 February 2013
- Print publication:
- 19 November 2009, pp 74-87
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Summary
Introduction
It is now well known (despite little mention in recent major works, including the current Oxford History of the British Empire) that anything between 30 and 40 million persons died in the wake of famine in India in the half-century following Britain's final military conquest of the Indian subcontinent in 1857. The earlier stages of the conquest and colonisation under the east India Company had also been marked by large-scale famines, in particular the shocking Bengal famine of 1769–70 in which something like 10 million people, or a third of the population, perished. The famines of 1784 (upper India), 1803–6 (Bombay), the 1830s (North India), 1854 (Madras), 1861 (North West), 1865 (Orissa), and 1876–8 (South and North-East) are only now finding an established place in the historiography of India. Although precolonial India had certainly known famine, their frequency, scale and magnitude expanded dramatically and seemingly in line with the disruption to indigenous social and economic structures that accompanied colonial interference and extractions, especially the heavy and unpredictable cost of land revenues.
Cornelius Walford the Victorian demographer calculated that British India experienced 34 separate famines, compared with only 17 recorded instances in the prior two millennia of Indian history. An early critic of British rule complained in 1776, anticipating a major plank of later Indian nationalism, that ‘famine, pestilence and the English have covered our land with horror and desolation’ (Arnold 1999: 99).
Roundtable Discussion of Richard J. Samuels's Machiavelli's Children: Leaders and Their Legacies in Italy and Japan
- T. J. Pempel, Sheldon Garon, Junko Kato, Yves Tiberghien, Richard J. Samuels
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- Journal:
- Journal of East Asian Studies / Volume 6 / Issue 1 / April 2006
- Published online by Cambridge University Press:
- 24 March 2016, pp. 1-29
- Print publication:
- April 2006
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Richard Samuels's book Machiavelli's Children: Leaders and Their Legacies in Italy and Japan raises a number of important issues concerning political leadership and the role individual leaders can play in a nation's history. The book won the 2003 Marraro Prize from the Society for Italian Historical Studies and the 2004 Jervis-Schroeder Prize for the best book in International History and Politics, awarded by the International History and Politics section of the American Political Science Association. This is a roundtable involving four critical essays and the author's response. Discussion centers on the book, its methods, its broader applicability, and the ways in which it dovetails with other intellectual concerns, particularly as these apply to contemporary East Asia.
On the mixing of a low Reynolds number biological jet with a quiescent outer bathing solution
- J. Richard Goldgraben, Sheldon Weinbaum
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- Journal:
- Journal of Fluid Mechanics / Volume 59 / Issue 1 / 5 June 1973
- Published online by Cambridge University Press:
- 29 March 2006, pp. 159-175
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Existing analyses of the very low Reynolds number Stokes jet, e.g. Birkhoff & Zarantonello (1957) and Förste (1963), have been confined to a single-component fluid satisfying the usual zero-slip boundary conditions at a solid surface. In contrast, the low Reynolds number biological jets which emerge from the pores and channels at the secreting surfaces of numerous human, animal and insect organs entail the movement of water and solute subject to novel boundary conditions that arise from the local osmotic driving forces at the secreting surfaces. These boundary conditions introduce a nonlinear coupling between the fluid momentum and solute conservation equations. This paper first discusses the fundamental dimensionless groups and length scales that characterize these biological jet flows and then examines in detail, using the technique of matched inner and outer expansions, one flow situation important in epithelial membrane transport, namely, the two-dimensional mixing of an inhomogeneous jet with a quiescent outer bathing solution which is bounded by a semi-permeable mem brane in the plane of the exit. The paper concludes with a discussion of other physiologically relevant problems which arise from different orderings of the length scales, and different overall geometrical configurations and flow conditions.
On the movement of water and solute in extracellular channels with filtration, osmosis and active transport
- Sheldon Weinbaum, J. Richard Goldgraben
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- Journal:
- Journal of Fluid Mechanics / Volume 53 / Issue 3 / 13 June 1972
- Published online by Cambridge University Press:
- 29 March 2006, pp. 481-512
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A quantitative two-dimensional theoretical model is developed to describe the movement of water and salt along the long narrow extracellular channels which appear to be a common structural feature of all epithelial membranes. This study examines the transport behaviour of both open and closed membrane systems as a function of the geometric specialization of the channel and the active transport site location under the influence of three driving forces: trans-membrane osmotic and hydrodynamic pressure differentials and active transport. The previous one-dimensional hydrodynamic model of Diamond & Bossert (1967) and Segel(1970) was confined to closed channel systems such as the gall bladder in which the only mechanism for water movement is local osmosis due to active transport.
Approximate analytical solutions are presented for long constant-area open channels in which the active transport sites have been idealized as point solute sources. A streamwise co-ordinate straining technique has been used in these solutions to describe the nonlinear effects of convection over long distances. Closed-form solutions are also presented for the pressure and solute concentration distributions within simplified models of channel constrictions with varying degrees of occlusion.
Numerical results of the model have been compared with Cole's (1961, 1962) in vivo and in vitro experiments on the rabbit ciliary body. Satisfying agreement with the measured values of the solute and water fluxes has been obtained for both the living eye and the excised ciliary body. These results strongly suggest that the formation of aqueous humour in the rabbit is a pressure-dependent process in which local osmosis due to active transport accounts for only one-third of the total aqueous flow. The model has also been applied to the gall bladder epithelium using more general boundary conditions than allowed for in the model of Diamond & Bossert. New solutions yielding a vanishing diffusional flux at the channel exit were obtained. However, the model, like that of Diamond & Bossert, does not provide a rational explanation as to how the water in the cell interior is replenished.